Copper Tripeptide
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Stimulates collagen, elastin, and glycosaminoglycan synthesis
Balances MMP/TIMP activity to remodel extracellular matrix and reduce scarring
Enhances fibroblast and keratinocyte proliferation and migration
Stimulates angiogenesis through VEGF-mediated pathways
Modulates inflammatory cytokines by downregulating NF-κB
Reduces oxidative stress via free radical scavenging and gene expression changes
Promotes hair follicle stem cell activation and prolongs anagen phase
Induces expression of regenerative and cytoprotective genes
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Stimulates collagen and elastin production for firmer, more youthful skin
Improves skin texture, tone, and elasticity
Enhances wound healing and tissue repair
Reduces fine lines and wrinkles
Supports scar softening and remodeling
Promotes angiogenesis, improving tissue oxygenation and nutrient delivery
Strengthens hair follicles and prolongs hair growth cycle
Reduces inflammation and oxidative damage
Improves skin hydration and barrier function
Safe and well tolerated with minimal systemic effects
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Skin rejuvenation (photoaging, fine lines, wrinkles, uneven texture)
Scar remodeling (acne, traumatic, or surgical scars)
Post-procedure recovery (microneedling, laser, chemical peel)
Hair loss (androgenetic alopecia, telogen effluvium)
Wound healing support (acute and chronic wounds)
Stretch mark reduction (striae distensae)
Adjunct in regenerative therapies (stem cells, PRP, exosomes)
Hyperpigmentation management (supportive role)
Dermal barrier repair in inflamed or sensitive skin
Prevention of delayed healing in high-risk populations (e.g., diabetics)
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Pickart L, et al. Regenerative and protective actions of the GHK-Cu peptide. Int J Mol Sci. 2018.
Dou Y, et al. The potential of GHK as an anti-aging peptide. Aging (Albany NY). 2020.
Liu T, et al. Thermodynamically stable ionic-liquid microemulsions enhance topical peptide delivery. Bioactive Materials. 2023.
Dymek M, et al. Liposomes as carriers of GHK-Cu tripeptide for cosmetic applications. Int J Mol Sci. 2023.
Zoughaib M, et al. Enhanced angiogenic effects of RGD, GHK peptides and Cu²⁺. Mater Sci Eng C. 2021.
Islam R, et al. GHK-Cu-modified silver nanoparticles promote wound healing. Colloids Surf B Biointerfaces. 2024.
Cong R, et al. Dimeric copper peptide hydrogel accelerates diabetic wound healing. Nat Commun. 2025.
Chen H, et al. Tripeptide–copper self-healing hydrogel promotes wound repair. BioDesign Research. 2025.
Rinaldi F, et al. Randomized controlled trial of a PRP-like cosmetic containing biomimetic hair peptides. J Dermatolog Treat. 2019.
Kuceki G, et al. Minoxidil-dutasteride-copper peptide tattooing improves hair regrowth. Dermatol Ther (Heidelb). 2025.
Pickart L, et al. GHK peptide as a natural modulator of gene expression. Clin Interv Aging. 2015.
DrugBank. Prezatide copper (DB14683): pharmacokinetics and elimination profile.