Copper Tripeptide

    • Stimulates collagen, elastin, and glycosaminoglycan synthesis

    • Balances MMP/TIMP activity to remodel extracellular matrix and reduce scarring

    • Enhances fibroblast and keratinocyte proliferation and migration

    • Stimulates angiogenesis through VEGF-mediated pathways

    • Modulates inflammatory cytokines by downregulating NF-κB

    • Reduces oxidative stress via free radical scavenging and gene expression changes

    • Promotes hair follicle stem cell activation and prolongs anagen phase

    • Induces expression of regenerative and cytoprotective genes

    • Stimulates collagen and elastin production for firmer, more youthful skin

    • Improves skin texture, tone, and elasticity

    • Enhances wound healing and tissue repair

    • Reduces fine lines and wrinkles

    • Supports scar softening and remodeling

    • Promotes angiogenesis, improving tissue oxygenation and nutrient delivery

    • Strengthens hair follicles and prolongs hair growth cycle

    • Reduces inflammation and oxidative damage

    • Improves skin hydration and barrier function

    • Safe and well tolerated with minimal systemic effects

    • Skin rejuvenation (photoaging, fine lines, wrinkles, uneven texture)

    • Scar remodeling (acne, traumatic, or surgical scars)

    • Post-procedure recovery (microneedling, laser, chemical peel)

    • Hair loss (androgenetic alopecia, telogen effluvium)

    • Wound healing support (acute and chronic wounds)

    • Stretch mark reduction (striae distensae)

    • Adjunct in regenerative therapies (stem cells, PRP, exosomes)

    • Hyperpigmentation management (supportive role)

    • Dermal barrier repair in inflamed or sensitive skin

    • Prevention of delayed healing in high-risk populations (e.g., diabetics)

    1. Pickart L, et al. Regenerative and protective actions of the GHK-Cu peptide. Int J Mol Sci. 2018.

    2. Dou Y, et al. The potential of GHK as an anti-aging peptide. Aging (Albany NY). 2020.

    3. Liu T, et al. Thermodynamically stable ionic-liquid microemulsions enhance topical peptide delivery. Bioactive Materials. 2023.

    4. Dymek M, et al. Liposomes as carriers of GHK-Cu tripeptide for cosmetic applications. Int J Mol Sci. 2023.

    5. Zoughaib M, et al. Enhanced angiogenic effects of RGD, GHK peptides and Cu²⁺. Mater Sci Eng C. 2021.

    6. Islam R, et al. GHK-Cu-modified silver nanoparticles promote wound healing. Colloids Surf B Biointerfaces. 2024.

    7. Cong R, et al. Dimeric copper peptide hydrogel accelerates diabetic wound healing. Nat Commun. 2025.

    8. Chen H, et al. Tripeptide–copper self-healing hydrogel promotes wound repair. BioDesign Research. 2025.

    9. Rinaldi F, et al. Randomized controlled trial of a PRP-like cosmetic containing biomimetic hair peptides. J Dermatolog Treat. 2019.

    10. Kuceki G, et al. Minoxidil-dutasteride-copper peptide tattooing improves hair regrowth. Dermatol Ther (Heidelb). 2025.

    11. Pickart L, et al. GHK peptide as a natural modulator of gene expression. Clin Interv Aging. 2015.

    12. DrugBank. Prezatide copper (DB14683): pharmacokinetics and elimination profile.